Quinine induced blindness

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The management of quinine-induced blindness.

Given the potential toxicity of even a small number of quinine tablets we suggest that patients to whom these are prescribed should be alerted to this risk both by the prescribing clinician and by a warning, clearly printed on the tablet container. There is no evidence that increased retinal arteriolar dilation is of any value in the management of patients with quinine induced blindness. Theref...

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Blindness from quinine toxicity.

We report a case of quinine overdose in a 47-year-old man who presented with blindness. Fundus photography demonstrates the acute and subsequent retinal changes, and his visual recovery to normal acuity with visual field constriction is documented. Pupillary and electrodiagnostic findings are recorded. Stellate ganglion block has been widely advocated as a helpful therapeutic measure, but out p...

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Recovery from blindness following accidental quinine overdose

CASE A 46-year-old woman presented with sudden loss of vision in both eyes, apparent since waking. She also complained of partial hearing loss. The previous evening she had experienced difficulty sleeping due to (long-standing) restless legs and had self-medicated with quinine, taking an accidental overdose of 1.8 g. On admission, she was alert but unable to perceive light in either eye, and ha...

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Death and blindness due to overdose of quinine.

During 1953-83 there were 48 admissions to the regional poisoning treatment centre, Edinburgh, for overdose of quinine including 19 since 1978. Six patients were blind and one had ventricular tachycardia. Stellate ganglion block was performed without benefit in seven patients. No patient died, but three deaths from cardiotoxicity occurred in a further 71 patients reported to the Scottish Poison...

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Quinine Induced Thrombotic Microangiopathy (TMA)

Quinine is the most common cause of Drug induced thrombotic microangiopathy (DITMA), being the offending drug in 33% of cases. We present a case of DITMA after only a single dose of quinine with no previous history of quinine exposure treated successfully with plasma exchange (PEX), oral corticosteroid followed by mycophenolatemofetil (MMF). The diagnosis was made by the close temporal relation...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1997

ISSN: 0007-1161

DOI: 10.1136/bjo.81.12.1029